Christopher P Leamon: search on Z-Library

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1

Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay

Nikki Parker, Mary Jo Turk, Elaine Westrick, Jeffrey D. Lewis, Philip S. Low, Christopher P. Leamon

Journal:

Analytical Biochemistry

Year:

2005

Language:

english

File:

PDF, 402 KB

english, 2005

2

Ligand-Targeted Delivery of Small Interfering RNAs to Malignant Cells and Tissues

Mini Thomas, Sumith A. Kularatne, Longwu Qi, Paul Kleindl, Christopher P. Leamon, Michael J. Hansen, Philip S. Low

Journal:

Annals of the New York Academy of Sciences

Year:

2009

Language:

english

File:

PDF, 556 KB

english, 2009

3

Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part 1: EC145, a folic acid conjugate of desacetylvinblastine monohydrazide

Iontcho R. Vlahov, Hari Krishna R. Santhapuram, Paul J. Kleindl, Stephen J. Howard, Katheryn M. Stanford, Christopher P. Leamon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 260 KB

english, 2006

4

Folate-mediated targeting: from diagnostics to drug and gene delivery

Christopher P. Leamon, Philip S. Low

Journal:

Drug Discovery Today

Year:

2001

Language:

english

File:

PDF, 624 KB

english, 2001

5

[Vitamins & Hormones] Folic Acid and Folates Volume 79 || Chapter 7 Exploitation of the Folate Receptor in the Management of Cancer and Inflammatory Disease

Leamon, Christopher P.

Year:

2008

Language:

english

File:

PDF, 661 KB

english, 2008

6

The folate receptor as a rational therapeutic target for personalized cancer treatment

Assaraf, Yehuda G., Leamon, Christopher P., Reddy, Joseph A.

Journal:

Drug Resistance Updates

Year:

2014

Language:

english

File:

PDF, 1.04 MB

english, 2014

7

An Assembly Concept for the Consecutive Introduction of Unsymmetrical Disulfide Bonds: Synthesis of a Releasable Multidrug Conjugate of Folic Acid

Vlahov, Iontcho R., Santhapuram, Hari Krishna R., Wang, Yu, Kleindl, Paul J., You, Fei, Howard, Stephen J., Westrick, Elaine, Reddy, Joseph A., Leamon, Christopher P.

Journal:

Journal of Organic Chemistry

Year:

2007

Language:

english

File:

PDF, 206 KB

english, 2007

8

Folate–Vinca Alkaloid Conjugates for Cancer Therapy: A Structure–Activity Relationship

Leamon, Christopher P., Vlahov, Iontcho R., Reddy, Joseph A., Vetzel, Marilynn, Santhapuram, Hari Krishna R., You, Fei, Bloomfield, Alicia, Dorton, Ryan, Nelson, Melissa, Kleindl, Paul, Vaughn, Jeremy

Journal:

Bioconjugate Chemistry

Year:

2014

Language:

english

File:

PDF, 3.42 MB

english, 2014

9

Synthesis and Biological Evaluation of EC20: A New Folate-Derived, 99m Tc-Based Radiopharmaceutical

Leamon, Christopher P., Parker, Matthew A., Vlahov, Iontcho R., Xu, Le-Cun, Reddy, Joseph A., Vetzel, Marilynn, Douglas, Nikki

Journal:

Bioconjugate Chemistry

Year:

2002

Language:

english

File:

PDF, 191 KB

english, 2002

10

Acid mediated formation of an N-acyliminium ion from tubulysins: A new methodology for the synthesis of natural tubulysins and their analogs

Iontcho R. Vlahov, Yu Wang, Marilynn Vetzel, Spencer Hahn, Paul J. Kleindl, Joseph A. Reddy, Christopher P. Leamon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 585 KB

english, 2011

11

Regioselective synthesis of folate receptor-targeted agents derived from epothilone analogs and folic acid

Iontcho R. Vlahov, Gregory D. Vite, Paul J. Kleindl, Yu Wang, Hari Krishna R. Santhapuram, Fei You, Stephen J. Howard, Soong-Hoon Kim, Francis F.Y. Lee, Christopher P. Leamon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 467 KB

english, 2010

12

Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters

Lee, Yong Gu, Chu, Haiyan, Lu, Yingjuan, Leamon, Christopher P., Srinivasarao, Madduri, Putt, Karson S., Low, Philip S.

Journal:

Nature Communications

Year:

2019

Language:

english

File:

PDF, 879 KB

english, 2019

13

In vitro and in vivo evaluation of a novel 67Ga-DOTA-folate in KB-tumor bearing mice

Cristina Müller, Christopher P. Leamon, Roger Schibli

Journal:

Nuclear Medicine and Biology

Year:

2010

Language:

english

File:

PDF, 66 KB

english, 2010

14

Synthesis and Biological Evaluation of EC72: A New Folate-Targeted Chemotherapeutic

Leamon, Christopher P., Reddy, Joseph A., Vlahov, Iontcho R., Vetzel, Marilynn, Parker, Nikki, Nicoson, Jeffrey S., Xu, Le-Cun, Westrick, Elaine

Journal:

Bioconjugate Chemistry

Year:

2005

Language:

english

File:

PDF, 255 KB

english, 2005

15

The changing landscape of cancer drug discovery: a challenge to the medicinal chemist of tomorrow

Klaus Pors, Frederick W. Goldberg, Christopher P. Leamon, Alan C. Rigby, Scott A. Snyder, Robert A. Falconer

Journal:

Drug Discovery Today

Year:

2009

Language:

english

File:

PDF, 133 KB

english, 2009

16

Folate-Targeted Dinitrophenyl Hapten Immunotherapy: Effect of Linker Chemistry on Antitumor Activity and Allergic Potential

Lu, Yingjuan, You, Fei, Vlahov, Iontcho, Westrick, Elaine, Fan, Mingjin, Low, Philip S., Leamon, Christopher P.

Journal:

Molecular Pharmaceutics

Year:

2007

Language:

english

File:

PDF, 511 KB

english, 2007

17

In Vivo Structural Activity and Optimization Studies of Folate−Tubulysin Conjugates

Reddy, Joseph A., Dorton, Ryan, Dawson, Alicia, Vetzel, Marilynn, Parker, Nikki, Nicoson, Jeffrey S., Westrick, Elaine, Klein, Patrick J., Wang, Yu, Vlahov, Iontcho R., Leamon, Christopher P.

Journal:

Molecular Pharmaceutics

Year:

2009

Language:

english

File:

PDF, 654 KB

english, 2009

18

Folate receptor-beta expression as a diagnostic target in human & rodent nonalcoholic steatohepatitis

Lake, April D., Hardwick, Rhiannon N., Leamon, Christopher P., Low, Philip S., Cherrington, Nathan J.

Journal:

Toxicology and Applied Pharmacology

Year:

2019

Language:

english

File:

PDF, 4.87 MB

english, 2019

19

Comparative preclinical activity of the folate-targeted Vinca alkaloid conjugates EC140 and EC145

Christopher P. Leamon, Joseph A. Reddy, Iontcho R. Vlahov, Elaine Westrick, Nikki Parker, Jeffrey S. Nicoson, Marilynn Vetzel

Journal:

International Journal of Cancer

Year:

2007

Language:

english

File:

PDF, 418 KB

english, 2007

20

Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part II: Folic acid conjugates of tubulysins and their hydrazides

Iontcho R. Vlahov, Yu Wang, Paul J. Kleindl, Christopher P. Leamon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 493 KB

english, 2008

21

Preclinical Antitumor Activity of a Novel Folate-Targeted Dual Drug Conjugate

Leamon, Christopher P., Reddy, Joseph A., Vlahov, Iontcho R., Westrick, Elaine, Dawson, Alicia, Dorton, Ryan, Vetzel, Marilynn, Santhapuram, Hari Krishna, Wang, Yu

Journal:

Molecular Pharmaceutics

Year:

2007

Language:

english

File:

PDF, 747 KB

english, 2007

22

Carbonic Anhydrase IX-Targeted Near-Infrared Dye for Fluorescence Imaging of Hypoxic Tumors

Mahalingam, Sakkarapalayam, Chu, Haiyan, Liu, Xin, Leamon, Christopher P., Low, Philip S.

Journal:

Bioconjugate Chemistry

Year:

2018

Language:

english

File:

PDF, 1.88 MB

english, 2018

23

Folate-mediated Drug Delivery: Effect of Alternative Conjugation Chemistry

Leamon, Christopher P., Deprince, Randolph B., Hendren, R. Wayne

Journal:

Journal of Drug Targeting

Year:

1999

Language:

english

File:

PDF, 1.07 MB

english, 1999

24

Development and validation of a UPLC–MS/MS method for the novel folate-targeted small molecule drug conjugate EC1456 and its metabolites in tumor homogenates from mice

Rao, Satish I., Pugh, Michael, Nelson, Melissa, Reddy, Joseph A., Klein, Patrick J., Leamon, Christopher P.

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2016

Language:

english

File:

PDF, 524 KB

english, 2016

25

Combining Highly Multiplexed PCR with Semiconductor-Based Sequencing for Rapid Cancer Genotyping

Beadling, Carol, Neff, Tanaya L., Heinrich, Michael C., Rhodes, Katherine, Thornton, Michael, Leamon, John, Andersen, Mark, Corless, Christopher L.

Journal:

The Journal of Molecular Diagnostics

Year:

2013

Language:

english

File:

PDF, 752 KB

english, 2013

26

Low-Dose Radiation Potentiates the Therapeutic Efficacy of Folate Receptor–Targeted Hapten Therapy

Emanuela I. Sega, Yingjuan Lu, Michael Ringor, Christopher P. Leamon, Philip S. Low

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2008

Language:

english

File:

PDF, 2.87 MB

english, 2008

27

Engineering Folate–Drug Conjugates to Target Cancer: From Chemistry to Clinic

Vlahov, Iontcho R., Leamon, Christopher P.

Journal:

Bioconjugate Chemistry

Year:

2012

Language:

english

File:

PDF, 2.42 MB

english, 2012

28

Delivery of Macromolecules into Living Cells: A Method that Exploits Folate Receptor Endocytosis

Christopher P. Leamon and Philip S. Low

Journal:

Proceedings of the National Academy of Sciences

Year:

1991

Language:

english

File:

PDF, 1.08 MB

english, 1991

29

Phase I/II clinical trial of the targeted chemotherapeutic drug, folate-tubulysin, in dogs with naturally-occurring invasive urothelial carcinoma

Szigetvari, Nicholas M., Dhawan, Deepika, Ramos-Vara, José A., Leamon, Christopher P., Klein, Patrick J., Ruple, A. Audrey, Heng, Hock Gan, Pugh, Michael R., Rao, Satish, Vlahov, Iontcho R., Deshuille

Journal:

Year:

2018

File:

PDF, 2.85 MB

2018

30

Targeted Drug Strategies for Cancer and Inflammation || Folate Receptor-Targeted Radionuclide Imaging Agents

Jackman, Ann L., Leamon, Christopher P.

Year:

2011

Language:

english

File:

PDF, 748 KB

english, 2011

31

Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic

Reddy, Joseph A., Dorton, Ryan, Bloomfield, Alicia, Nelson, Melissa, Dircksen, Christina, Vetzel, Marilynn, Kleindl, Paul, Santhapuram, Hari, Vlahov, Iontcho R., Leamon, Christopher P.

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 1.33 MB

english, 2018

32

Phase I/II clinical trial of the targeted chemotherapeutic drug, folate-tubulysin, in dogs with naturally-occurring invasive urothelial carcinoma

Szigetvari, Nicholas M., Dhawan, Deepika, Ramos-Vara, José A., Leamon, Christopher P., Klein, Patrick J., Ruple, A. Audrey, Heng, Hock Gan, Pugh, Michael R., Rao, Satish, Vlahov, Iontcho R., Deshuille

Journal:

Year:

2018

Language:

english

File:

PDF, 2.85 MB

english, 2018

33

Folate-Liposome-Mediated Antisense Oligodeoxynucleotide Targeting to Cancer Cells: Evaluation in Vitro and in Vivo

Leamon, Christopher P., Cooper, Scott R., Hardee, Gregory E.

Journal:

Bioconjugate Chemistry

Year:

2003

Language:

english

File:

PDF, 317 KB

english, 2003

34

Assessment of folate receptor expression and folate uptake in multicentric lymphomas in dogs

Childress, Michael O., Dhawan, Deepika, Leamon, Christopher P., Miller, Margaret A., Ramos-Vara, José A., Naughton, James F., Low, Philip S., Knapp, Deborah W.

Journal:

American Journal of Veterinary Research

Year:

2014

Language:

english

File:

PDF, 574 KB

english, 2014

35

Effects of the Antifolates Pemetrexed and CB3717 on the Tissue Distribution of 99m Tc-EC20 in Xenografted and Syngeneic Tumor-Bearing Mice †

Müller, Cristina, Reddy, Joseph A., Leamon, Christopher P., Schibli, Roger

Journal:

Molecular Pharmaceutics

Year:

2010

Language:

english

File:

PDF, 221 KB

english, 2010

36

Selective Targeting of Malignant Cells with Cytotoxin-Folate Conjugates

Leamon, Christopher, Low, Philip

Journal:

Journal of Drug Targeting

Year:

1994

Language:

english

File:

PDF, 3.70 MB

english, 1994

37

Folate receptor specific anti-tumor activity of folate–mitomycin conjugates

Joseph A. Reddy, Elaine Westrick, Iontcho Vlahov, Stephen J. Howard, Hari Krishna Santhapuram, Christopher P. Leamon

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2006

Language:

english

File:

PDF, 352 KB

english, 2006

38

Carbohydrate-Based Synthetic Approach to Control Toxicity Profiles of Folate−Drug Conjugates

Vlahov, Iontcho R., Santhapuram, Hari Krishna R., You, Fei, Wang, Yu, Kleindl, Paul J., Hahn, Spencer J., Vaughn, Jeremy F., Reno, Daniel S., Leamon, Christopher P.

Journal:

Journal of Organic Chemistry

Year:

2010

Language:

english

File:

PDF, 2.16 MB

english, 2010

39

Folate Copolymer-Mediated Transfection of Cultured Cells

Leamon, Christopher P., Weigl, Debra, Hendren, R. Wayne

Journal:

Bioconjugate Chemistry

Year:

1999

Language:

english

File:

PDF, 247 KB

english, 1999

40

Targeted Drug Strategies for Cancer and Inflammation || Folate Receptors and Therapeutic Applications

Jackman, Ann L., Leamon, Christopher P.

Year:

2011

Language:

english

File:

PDF, 342 KB

english, 2011

41

Design and regioselective synthesis of a new generation of targeted therapeutics. Part 3: Folate conjugates of aminopterin hydrazide for the treatment of inflammation

Iontcho R. Vlahov, Fei You, Hari Krishna R. Santhapuram, Yu Wang, Jeremy F. Vaughn, Spencer J. Hahn, Paul J. Kleindl, Mingjin Fan, Christopher P. Leamon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 546 KB

english, 2011

42

Folate-targeted chemotherapy

Christopher P Leamon, Joseph A Reddy

Journal:

Advanced Drug Delivery Reviews

Year:

2004

Language:

english

File:

PDF, 544 KB

english, 2004

43

Enhancing the therapeutic range of a targeted small-molecule tubulysin conjugate for folate receptor-based cancer therapy

Leamon, Christopher P., Reddy, Joseph A., Vlahov, Iontcho R., Dorton, Ryan, Bloomfield, Alicia, Vetzel, Marilynn, Klein, Patrick J., Westrick, Elaine, Xu, Le-cun, Wang, Yu

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2017

Language:

english

File:

PDF, 614 KB

english, 2017

44

Folate receptor-targeted immunotherapy of cancer: mechanism and therapeutic potential

Yingjuan Lu, Emanuela Sega, Christopher P. Leamon, Philip S. Low

Journal:

Advanced Drug Delivery Reviews

Year:

2004

Language:

english

File:

PDF, 605 KB

english, 2004

45

High-Throughput Quantitative Polymerase Chain Reaction in Picoliter Droplets

Kiss, Margaret Macris, Ortoleva-Donnelly, Lori, Beer, N. Reginald, Warner, Jason, Bailey, Christopher G., Colston, Bill W., Rothberg, Jonathon M., Link, Darren R., Leamon, John H.

Journal:

Analytical Chemistry

Year:

2008

Language:

english

File:

PDF, 1013 KB

english, 2008

46

Comparison of folate-conjugated rapamycin versus unconjugated rapamycin in an orthologous mouse model of polycystic kidney disease

Kipp, Kevin R, Kruger, Samantha L, Schimmel, Margaret F, Parker, Nikki, Shillingford, Jonathan M, Leamon, Christopher P, Weimbs, Thomas

Journal:

American journal of physiology. Renal physiology

Year:

2018

Language:

english

File:

PDF, 8.99 MB

english, 2018

47

Tumor targeting using 67Ga-DOTA-Bz-folate — investigations of methods to improve the tissue distribution of radiofolates

Cristina Müller, Iontcho R. Vlahov, Hari Krishna R. Santhapuram, Christopher P. Leamon, Roger Schibli

Journal:

Nuclear Medicine and Biology

Year:

2011

Language:

english

File:

PDF, 495 KB

english, 2011

48

Strategy to Prevent Drug-Related Hypersensitivity in Folate-Targeted Hapten Immunotherapy of Cancer

Yingjuan Lu, Patrick J. Klein, Elaine Westrick, Le-Cun Xu, Hari Krishna R. Santhapuram, Alicia Bloomfield, Stephen J. Howard, Iontcho R. Vlahov, P. Ron Ellis, Philip S. Low, Christopher P. Leamon

Journal:

The AAPS Journal

Year:

2009

Language:

english

File:

PDF, 396 KB

english, 2009

49

Clinical Pharmacokinetics and Exposure-Toxicity Relationship of a Folate- Vinca Alkaloid Conjugate EC145 in Cancer Patients

Li, Jing, Sausville, Edward A., Klein, Patrick J., Morgenstern, David, Leamon, Christopher P., Messmann, Richard A., LoRusso, Patricia

Journal:

Journal of Clinical Pharmacology

Year:

2009

Language:

english

File:

PDF, 334 KB

english, 2009

50

Properties Influencing the Relative Binding Affinity of Pteroate Derivatives and Drug Conjugates Thereof to the Folate Receptor

Christopher P. Leamon, Fei You, Hari Krishna Santhapuram, Mingjin Fan, Iontcho R. Vlahov

Journal:

Pharmaceutical Research

Year:

2009

Language:

english

File:

PDF, 677 KB

english, 2009

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